The cause of nephrotic syndrome transformate cute renal failure

Nephrotic syndrome may be complicated by infection, acute renal failure, renal tubular dysfunction, bone and calcium metabolism, endocrine and metabolic abnormalities, including acute renal failure in patients with nephrotic syndrome, the most serious complication, once patients with acute renal failure , often in need of dialysis treatment. Common cause of nephrotic syndrome in patients with acute renal failure have hemodynamic changes in renal interstitial edema, vascular contraction.

First, interstitial edema: hypoproteinemia can cause peripheral edema, will also lead to renal interstitial edema, interstitial edema and tubular pressure, so that the proximal tubule Bowman capsule hydrostatic pressure increased, GFR decline.

Second, vasoconstriction: Some patients with nephrotic syndrome see when hypoproteinemia renin concentration, renin renal small arteries, GFR decline. The presence of vascular lesions more common in the elderly.

Third, hemodynamic changes: patients with nephrotic syndrome often have hypoproteinemia and vascular lesions, especially in elderly patients with renal arteriosclerosis, blood volume and blood pressure is very sensitive, so when acute blood loss, vomiting and diarrhea are caused by loss of body fluids, surgical injury, ascites, a large number of diuretic and antihypertensive drugs, blood pressure can drop further, leading to a sharp reduction in renal perfusion, thus reducing the glomerular filtration rate, and due to acute ischemia and tubular epithelial cell swelling, degeneration and necrosis, leading to acute renal failure.

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