What prompted the deterioration factor is chronic renal failure?

Chronic renal disease, if not treated properly, it will be transformed into uremia. But there are many factors which worsen, and not just treat the problem, then what are the reasons for the deterioration prompted it?

1, high blood pressure causes: hypertension can not only speed up the progress of renal damage, and damage to the heart, brain, peripheral blood vessels and other organs, the prognosis of patients with chronic renal failure in general.

2, proteinuria reasons: for this factor can be proven within the tubular fluid excess albumin, transferrin and other harmful substances can lead to renal tubules, resulting in glomerular and tubular damage to be stimulate kidney growth factors such as: TGF-β secretion, and promote progression of renal fibrosis.

3, high-protein diet causes: Experts point out that high-protein diet can cause glomerular filtration state, glomerular metabolism, increased proteinuria, and renal tissue injury aggravated, is an important factor in the progression of chronic renal failure one.

4, uremic toxins Cause: This is one of the factors prompting the deterioration of chronic renal failure, chronic renal failure in patients with end-stage uremia, due to various toxins in the body retention, which in turn will accelerate kidney function, and other organizations further damage to organs.

5, hyperlipidemia Cause: For this reason, presumably not many people know, high cholesterol can lead to glomerular mesangial cells and endothelial cell injury. A certain concentration of oxidized LDL can stimulate mesangial cells to secrete extracellular matrix, or induction of apoptosis of mesangial, thereby promoting progression of renal fibrosis.

6 other reasons: factors anemia, malnutrition, also may contribute to the progression of chronic renal failure.
Through the above description, the factors for chronic renal failure and deterioration of the disease, surely we have been very clear now.

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